Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility

Type: Literature review

Author:  Noel L. Smith1, Anthony L. Wilson2, Jason Gandhi2, 3, Sohrab Vatsia4, Sardar Ali Khan2,


O3 therapy can alter the natural history of several disease and disorders, with potentially many more yet untested. A plethora of laboratory studies have provided evidence of O3's antioxidant capabilities, as well as vascular, haematological, and immune system modulations. This evidence has been further substantiated in clinical trials with O3 therapy being useful in the cardiovascular, subcutaneous tissue, peripheral vascular disease, neurological, head and neck, orthopaedic, gastrointestinal, and genitourinary pathologies. O3 therapy has proven especially beneficial in the diabetic foot, ischemic wounds, and peripheral vascular disease, areas in which O3 use is most prevalent.

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