Effectiveness of Ozone Therapy as an Adjunct Treatment for Lower-Limb Ulcers: A Systematic Review

Type: Journal article

Author:  Tássia Lima Bomfim 1Isla Alcântara GomesDaniele de Vasconcelos Cerqueira MenesesAdriano Antunes de Souza Araujo


Data synthesis: A total of 506 patients 18 years or older with chronic wounds, such as venous or diabetic ulcers, on the lower limbs were enrolled. The majority of studies addressed diabetic foot ulcers.

Conclusions: The ozone therapy protocols demonstrated a healing effect in all included studies, and none reported adverse effects. This reinforces the need for more controlled and randomized clinical trials to determine the effectiveness of this treatment and establish clinical criteria for its use.

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