Our Standards: ISCO3, the Madrid Declaration & OTANZ
Ozone therapy at home should be practised the same way it is practised in clinics that do it well: within published guidelines, at established doses, with a clear understanding of who it suits and who it does not. This page sets out the framework Natural Ozone works within, and the support available when you want advice specific to your situation.
The Madrid Declaration on Ozone Therapy
The Madrid Declaration on Ozone Therapy is the international reference document for the practice of ozone therapy, published by the International Scientific Committee of Ozone Therapy (ISCO3). The current 4th edition, approved in 2025, runs to 196 pages and sets out therapeutic ranges, application routes, contraindications and safety principles – its subtitle is “For the Unification of Criteria in the Practice of Ozone Therapy”.
Natural Ozone is registered with ISCO3, and our Home Ozone Therapy Protocols Handbook is aligned to the 4th edition. In practice, that means:
- Low-dose ranges, not maximums. Ozone’s benefit comes from small, controlled doses within an established therapeutic window – more is not better. Every protocol we publish works within the Declaration’s ranges.
- Start low, go slow. Protocols begin at the gentle end of each range and build gradually.
- Ozone is never inhaled. Every home protocol delivers ozone without it reaching the lungs. This is the one absolute rule of ozone therapy.
- We tell you who it is not for. See below.
Who ozone therapy is not for
The Madrid Declaration (4th edition, §2.1) lists the situations in which systemic ozone therapy is contraindicated – that is, should not be used:
- Direct inhalation of ozone gas – ozone must never be breathed in
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency, also known as favism
- Toxic hyperthyroidism (severe Basedow / Graves’ disease)
- Thrombocytopenia (platelet count below 50,000) and severe coagulation disorders
- Severe cardiovascular instability
- Acute alcohol intoxication
- Recent acute myocardial infarction (heart attack)
- Acute massive haemorrhage
- During convulsive states
- Haemochromatosis
- While receiving intravenous copper or iron therapy
If any of these apply to you, ozone therapy is not the right tool – and we would rather tell you that plainly than sell you equipment. If you are unsure whether something on this list applies to you, talk to your doctor before going any further.
Ozone Therapy Association of New Zealand
Natural Ozone is registered with the Ozone Therapy Association of New Zealand (OTANZ).
Personalised advice from a doctor or ozone therapist
If you are managing a health condition and want guidance on whether ozone therapy is appropriate for you – and if so, which protocols and what setup – a consultation is the right place to start.
We work with Dr Andrew Lucas (MBChB, FRACGP, FRNZCGP), a registered GP practising integrative medicine with over 25 years of clinical experience, who is available for phone consultations for personalised protocol advice. Consultations are arranged with Dr Lucas directly through his practice, the Ozone Therapy Centre.
You can also consult any of the ozone therapists registered with OTANZ – find one near you in the OTANZ practitioner directory.
Read the research yourself
Our Knowledge Centre hosts the published studies behind each protocol – around 130 papers, reviews and clinical studies, searchable by condition. We encourage you to read the research before you buy anything: our customers make better decisions when they do.
The information on this page is educational and is not a substitute for medical advice. If you are managing a health condition, we encourage you to work alongside your healthcare practitioner. Natural Ozone follows the guidelines of the International Scientific Committee of Ozone Therapy (ISCO3).