The Role of Mitochondria in Ozone Therapy
Type: Literature review
Author: Oliveira MM1 and Peixoto F2*
Summary:
Ozone concentration and effects do not follow a linear relationship:
very low concentrations have no effect. However, high
concentrations can lead to harmful effects contrary to the
benefic effects observed at the medium/low concentration
[48]. It is essential to understand the proper relationship
between ozone and endogenous antioxidants to define the
proper concentration of ozone to be administered. Although
the mechanisms by which ozone can model mitochondrial
function and redox balance are not yet fully understood, there
is numerous evidence for this capability. It is also evident
that the impact of ozone depends on the concentration,
duration of treatment, exposure route, target organ and
animal model used in the study. Therefore, it is essential to
carry out further studies using different animal models and
different concentrations and routes of ozone administration
to understand the molecular mechanism underlying the
observed effects on mitochondria.