Physico-Chemical Investigation and Antimicrobial Efficacy of Ozonated Oils: The Case Study of Commercial Ozonated Olive and Sunflower Seed Refined Oils

Type: Case Study

Author: Silvia Puxeddu 1,†, Alessandra Scano 2,3,† , Mariano Andrea Scorciapino 2 , Ilenia Delogu 1 , Sarah Vascellari 1 , Guido Ennas 2,3 , Aldo Manzin 1 and Fabrizio Angius


Our study investigated the physico-chemical properties and antimicrobial activity of two commercial ozonated sunflower and olive oils, against C. albicans, E. faecalis, S. aureus, K. pneumoniae, P. aeruginosa, and E. coli. Both ozonated oils exhibited high microbicidal effects against C. albicans and E. faecalis, while they were active also against S. aureus and E. coli. Moreover, the cell viability assay showed no cytotoxicity in keratinocytes and epithelial cells. These results make the two oils studied promising for a wide range of applications in medicine and healthcare such as treatment of common infections, likely overcoming drug resistance issues. The treatment of vegetable oils with ozone creates a reservoir of antimicrobial species active against diverse microorganisms. In this scenario, further studies will be run on the delivery of the two ozonated oils by different pharmaceutical formulations.

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