Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription

Type: Journal article

Author: M. Costanzo,1 B. Cisterna,1 A. Vella,2 T. Cestari,2 V. Covi,3 G. Tabaracci,3 M. Malatesta1


Our results confirm that the effects of ozone administration are dependent on gas concentration, and demonstrate that the nucleus and the cytoplasmic organelles may be differently affected. We are well aware that these data have been obtained in an in vitro cell model and cannot be directly translated to the application in vivo for therapy; nonetheless, the evidence from the present experiments suggests that protocols of ozone administration may be developed to predictively ensure effective and permanent metabolic cell activation.

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