Effectiveness of complex treatment associated with ozone therapy on clinical indicators and immunity status in children with atopic dermatitis and concomitant allergic rhinitis
Author: Illek Y.Y.1, Suetina I.G.1, Khlebnikova N.V.1, Suslova E.V.1, Galanina A.V.2
Summary
Conclusions The inclusion of ozone therapy in the comprehensive treatment of preschool and primary school children suffering from moderate-to-severe atopic dermatitis and concomitant moderate-to-severe persistent allergic rhinitis ensures a faster onset of clinical remission. During the period of clinical remission in the second group of patients with atopic dermatitis and concomitant persistent allergic rhinitis who received comprehensive treatment in combination with ozone therapy, in contrast to the first group of patients with atopic dermatitis and concomitant persistent allergic rhinitis who received standard comprehensive therapy, normalization of most immune parameters is recorded. In the second group of patients with atopic dermatitis and concomitant persistent allergic rhinitis who received comprehensive treatment in combination with ozone therapy, a pronounced increase in the expression of Toll-like receptor-2 and Toll-like receptor-6 on lymphocytes, monocytes, and neutrophils is observed during the period of clinical remission, which indicates an increase in non-specific antibacterial resistance.